
Spotlight on:
The American Autoimmune Related Diseases Association (AARDA)
What is autoimmunity?
One of the functions of the immune system is to protect the body by responding to invading microorganisms, such as viruses or bacteria, by producing antibodies or sensitized lymphocytes (types of white blood cells).
Under normal conditions, an immune response cannot be triggered against the cells of one’s own body.
In certain cases, however, immune cells make a mistake and attack the very cells that they are meant to protect. This can lead to a variety of autoimmune diseases. They encompass a broad category of related diseases in which the person’s immune system attacks his or her own tissue.
What causes autoimmunity?
The immune system normally can distinguish “self” from “non-self.” Some lymphocytes are capable of reacting against self, resulting in an autoimmune reaction. Ordinarily these lymphocytes are suppressed. Autoimmunity occurs naturally in everyone to some degree; and in most people, it does not result in diseases.
Autoimmune diseases occur when there is some interruption of the usual control process, allowing lymphocytes to avoid suppression, or when there is an alteration in some body tissue so that it is no longer recognized as “self” and is thus attacked. The exact mechanisms causing these changes are not completely understood; but bacteria, viruses, toxins, and some drugs may play a role in triggering an autoimmune process in someone who already has a genetic (inherited) predisposition to develop such a disorder. It is theorized that the inflammation initiated by these agents, toxic or infectious, somehow provokes in the body a “sensitization” (autoimmune reaction) in the involved tissues.
What are the types of autoimmunity?
Particular autoimmune disorders are frequently classified into organ-specific disorders and non-organ-specific types. Autoimmune processes can have various results, for example, slow destruction of a specific type of cells or tissue, stimulation of an organ into excessive growth, or interference in its function. Organs and tissues frequently affected include the endocrine gland, such as thyroid, pancreas, and adrenal glands; components of the blood, such as red blood cells; and the connective tissues, skin, muscles, and joints. Some autoimmune diseases fall between the two types. Patients may experience several organ-specific diseases at the same time. There is, however little overlap between the two ends of the spectrum.
In organ-specific disorders, the autoimmune process is directed mostly against one organ. Examples, with the organ affected, include Hashimoto’s thyroiditis (thyroid gland), pernicious anemia (stomach), Addison’s disease (adrenal glands), and type 1 diabetes (pancreas).In non-organ-specific disorders, autoimmune activity is widely spread throughout the body. Examples include rheumatoid arthritis, systemic lupus erythematosus (SLE or lupus), and dermatomyositis.
What are some of the treatments for autoimmune diseases?
Of first importance in treating any autoimmune disease is the correction of any major deficiencies. An example would be replacing hormones that are not being produced by the gland, such as thyroxin in autoimmune thyroid disease or insulin in type 1 diabetes. In autoimmune blood disorders, treatment may involve replacing components of the blood by transfusion.
Second in importance is the diminishing of the activity of the immune system. This necessitates a delicate balance, controlling the disorder while maintaining the body’s ability to fight disease in general. The drugs most commonly used are corticosteroid drugs. More severe disorders can be treated with other more powerful immunosuppressant drugs, such as methotrexate, cyclophosphamide, and azathioprine.
All of these drugs, however, can damage rapidly dividing tissues, such as the bone marrow, and so are used with caution. Intravenous immunoglobulin therapy is used in the treatment of various autoimmune diseases to reduce circulating immune complexes. Some mild forms of rheumatic autoimmune diseases are treated by relieving the symptoms with nonsteroidal anti-inflammatory medications. Drugs that act more specifically on the immune system, for example, by blocking a particular hypersensitivity reaction, are being researched.What is the family connection in autoimmune diseases?
The ability to develop an autoimmune disease is determined by a dominant genetic trait that is very common (20 percent of the population) that may present in families as different autoimmune diseases within the same family. The genetic predisposition alone does not cause the development of autoimmune diseases. It seems that other factors need to be present as well in order to initiate the disease process. It is important for families with members who have an autoimmune disease to mention this fact when another member of the family is experiencing medical problems that appear to be difficult to diagnose.
How many Americans have an autoimmune disease?Approximately 50 million Americans, 20 percent of the population or one in five people, suffer from autoimmune diseases. Women are more likely than men to be affected; some estimates say that 75 percent of those affected–some 30 million people–are women. Still, with these statistics, autoimmunity is rarely discussed as a women’s health issue.
What is AARDA?
AARDA (The American Autoimmune Related Diseases Association) is a 501(C)(3) nonprofit organization. AARDA was founded in 1991 to increase awareness about autoimmune diseases. Today it has grown to become the premiere national organizationn on the forefront of autoimmune disease awareness, treatment, research, advocacy and patient information.
What are the goals of AARDA?
The American Autoimmune Releated Diseases Association’s goals are set forth in our Mission Statement:
AARDA is dedicated to the eradication of autoimmune diseases and the alleviation of suffering and the socioeconomic impact of autoimmunity through fostering and facilitating collaboration in the areas of education, public awareness, research, and patient services in an effective, ethical and efficient manner.How is AARDA funded?
AARDA receives one hundred percent of its annual funding requirements from contributions and donations made by people such as yourself. We are proud that AARDA provides substantial services with very low overhead. At AARDA, over 92% of all contributions are used for research, education and patient services. We are able to accomplish this efficiency because we are staffed primarily with volunteers.
Is AARDA associated with the government?AARDA is a private nonprofit organization. It is not associated with any State or Federal governmental agency. AARDA does, however, advocate for passage of legislation important to autoimmune research and patients suffering from an autoimmune disease.




26 Feb
Comments worth posting – a special thank you from The Northport Project to Shayla
Posted by The Northport Project - Jamie Paparich in BEST COMMENTS, IBD (COLITIS/ CROHN'S) STUDY, NORTHPORT, WASHINGTON, NPP SUPPORTERS!, THE NORTHPORT PROJECT. Tagged: CCFA, Colitis crohn's research database survey ccfa, Crohn's & Colitis Foundation of America, Crohn's disease, DOH, ECOLOGY, EPA, Inflammatory bowel disease, juvenile rheumatoid arthritis, Lake Roosevelt, Northport, Northport IBD Study, Northport Project, Shayla Phillips, TECK SMELTER, Ulcerative colitis, upper columbia river study, WA, Wa State DOH, Washington. Leave a Comment
Comment from Shayla Phillips:
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Response submitted by The Northport Project | In reply to Shayla.
Hi Shayla –
Thank you for all the support you and your family have given me. It is actually because of you and your brother that The Northport Project even exists.
A few months after I began The Northport Project in 2008, I was so frustrated with the lies and misconceptions the DOH and EPA had told the kind people of Northport, along with the difficulty in getting past and present residents to fill out health questionnaires in order to move forward, I almost just gave up.
It was then that your Mom e-mailed me and told me of your brother’s diagnosis with Ulcerative Colitis and about your struggle with juvenile rheumatoid arthritis. That was the push I needed to not only keep going but to start pushing harder for the information the DOH and EPA were trying to avoid providing me and to push the past and present Northport residents to take the time to complete the questionnaires, necessary to get the information necessary to get epidemiological studies done in the area. Two years later we were able to get two physicians from the Crohn’s & Colitis Center at Massachusetts General Hospital to conduct the first phase of their epidemiological study of Northport residents, past and present, diagnosed with Ulcerative Colitis and Crohn’s disease. The Northport IBD Study, (designed specifically for Northport), just concluded phase I of this study, in which the physicians were able to conclude that there is a health cluster of these diseases currently in the community, and that there has been a consistent cluster of these diseases since approx. 1955-60. With this information they are currently preparing an abstract, which will be used to obtain grants and funding for phase II, and eventually a manuscript of their findings. The results of this study could very likely help in discovering the cause, or specific triggers, of Ulcerative Colitis and Crohn’s disease, still unknown to the medical and scientific community.
So it is you I should be thanking. It is because of your Mom and her description of the suffering both you and your brother have endured so courageously. As well as your parents unselfishness to contact me to contribute whatever information they could in order to ensure this did not happen to any other children. They were not looking to blame anyone, or for compensation for the pain and suffering your family had endured (although they have every right to!), they honestly just wanted to help.
So thank you sweetie – and please feel free to e-mail me anytime – jamie_paparich@hotmail.com
Sincerely,
Jamie Paparich
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